The following article was seen on page eight of the RhyDin Post, September the tenth.
http://i738.photobucket.com/albums/xx21/dfenner_photo/handsomedoctor.jpg RhyDin Health Journalist: Dr. Arshad Herat
Zombification Possibly Linked to Lysosomal Storage Diseases September 10, 2010
New research done by a team of microbiologists at West End University reveals that the source of zombification may possibly be attributed to lysosomal storage diseases and programmed cell death.
The study, done over the course of a year, focused primarily on the microscopic effects of the L.S.B.9 condition (colloquially known as zombification), and its underlying connections to autophagy and autolysis of physiological humanoid cells.
"We managed to isolate the effects of the disease on a cellular level," Dr. Imam Jersuele, clinical researcher in WEU's pathology department, said. "While we haven't found the exact cause of the virus, we were able to determine that variations of it act specifically on a very important structure within the cell body called a lysosome."
Lysosomes are spherical organelles found within animal cells that contain acid hydrolases (enzymes) that engulf endocytized materials and cellular debris*. In a healthy cell, lysosomes function primarily in waste disposal, and digest worn-out organelles, food particles, and engulfed viruses or bacteria.
When a lysosome's function is compromised - if certain digestive enzymes are lacking within the structure or if it is damaged in some way - digestive enzymes contained within the lysosome are released into cellular cytoplasm, triggering rapid cell death (also known as autolysis).
According to Jersuele, the zombification condition is inherently tied lysosomal mutation.
"Using a very powerful microscope, we observed the injection of the L.S.B.9 pathogen into a sample of healthy skeletal tissue. What we found out was very interesting. While test results did indicate that the pathogen directly inhibits lysosomal function and contributes to RCD, the autolysis only affected about sixty-five percent of the cells, leaving the other cells within the sample perfectly viable and uncontaminated."
Jersuele attributes the "shuffling gait" and limited mobility of some L.S.B.9 patients to this anomaly.
"We have as of yet been unable to determine why the pathogen affects only certain cells. For example, we know that it deliberately impairs certain neurological and glial cells within the cerebrum - a part of the brain involved in reason and higher brain function - but it leaves the hypothalamus completely intact."
The hypothalamus is responsible for the regulation of body temperature, thirst, and hunger.
While several questions regarding the condition still remain unanswered, Jersuele remains confident that the microbiological discovery the WEU team has made is a pivotal step on the way to a cure.
"Now that we know exactly what part of the cell the pathogen impacts, we can work on trying to reverse its effects."
Currently, the L.S.B.9 affliction affects one in six hundred RhyDin residents.
*Source.]]
http://i738.photobucket.com/albums/xx21/dfenner_photo/handsomedoctor.jpg RhyDin Health Journalist: Dr. Arshad Herat
Zombification Possibly Linked to Lysosomal Storage Diseases September 10, 2010
New research done by a team of microbiologists at West End University reveals that the source of zombification may possibly be attributed to lysosomal storage diseases and programmed cell death.
The study, done over the course of a year, focused primarily on the microscopic effects of the L.S.B.9 condition (colloquially known as zombification), and its underlying connections to autophagy and autolysis of physiological humanoid cells.
"We managed to isolate the effects of the disease on a cellular level," Dr. Imam Jersuele, clinical researcher in WEU's pathology department, said. "While we haven't found the exact cause of the virus, we were able to determine that variations of it act specifically on a very important structure within the cell body called a lysosome."
Lysosomes are spherical organelles found within animal cells that contain acid hydrolases (enzymes) that engulf endocytized materials and cellular debris*. In a healthy cell, lysosomes function primarily in waste disposal, and digest worn-out organelles, food particles, and engulfed viruses or bacteria.
When a lysosome's function is compromised - if certain digestive enzymes are lacking within the structure or if it is damaged in some way - digestive enzymes contained within the lysosome are released into cellular cytoplasm, triggering rapid cell death (also known as autolysis).
According to Jersuele, the zombification condition is inherently tied lysosomal mutation.
"Using a very powerful microscope, we observed the injection of the L.S.B.9 pathogen into a sample of healthy skeletal tissue. What we found out was very interesting. While test results did indicate that the pathogen directly inhibits lysosomal function and contributes to RCD, the autolysis only affected about sixty-five percent of the cells, leaving the other cells within the sample perfectly viable and uncontaminated."
Jersuele attributes the "shuffling gait" and limited mobility of some L.S.B.9 patients to this anomaly.
"We have as of yet been unable to determine why the pathogen affects only certain cells. For example, we know that it deliberately impairs certain neurological and glial cells within the cerebrum - a part of the brain involved in reason and higher brain function - but it leaves the hypothalamus completely intact."
The hypothalamus is responsible for the regulation of body temperature, thirst, and hunger.
While several questions regarding the condition still remain unanswered, Jersuele remains confident that the microbiological discovery the WEU team has made is a pivotal step on the way to a cure.
"Now that we know exactly what part of the cell the pathogen impacts, we can work on trying to reverse its effects."
Currently, the L.S.B.9 affliction affects one in six hundred RhyDin residents.
*Source.]]